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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC7 All Species: 10.3
Human Site: S498 Identified Species: 28.33
UniProt: O00311 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00311 NP_001127891.1 574 63888 S498 E K T D H K A S C L V Q T P P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001097186 574 63766 S498 E K T D H K A S R L I Q T P P
Dog Lupus familis XP_537080 756 83548 S680 E K T D H K A S H L I Q T P Q
Cat Felis silvestris
Mouse Mus musculus Q9Z0H0 564 62734 A488 S K N T D H K A S R V Q A A Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521163 410 45484 G335 Q Q V A P R A G T P G F R A P
Chicken Gallus gallus XP_422347 564 62394 A489 E S A L P V E A D K Q C A P V
Frog Xenopus laevis NP_001081878 483 53563 D408 M R I M E N Q D G W F L P E S
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785538 591 65818 S516 S Q S N G E S S K R R R R S I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P06243 507 58302 Q432 A Y E L K K Y Q E E I W S D H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96.8 68.9 N.A. 78 N.A. N.A. 61.3 67.2 55.4 N.A. N.A. N.A. N.A. N.A. 36.7
Protein Similarity: 100 N.A. 97.7 71.5 N.A. 84.8 N.A. N.A. 65.6 78.7 66.9 N.A. N.A. N.A. N.A. N.A. 54.4
P-Site Identity: 100 N.A. 86.6 80 N.A. 20 N.A. N.A. 13.3 13.3 0 N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 N.A. 93.3 86.6 N.A. 26.6 N.A. N.A. 33.3 20 6.6 N.A. N.A. N.A. N.A. N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 39.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 12 12 0 0 45 23 0 0 0 0 23 23 0 % A
% Cys: 0 0 0 0 0 0 0 0 12 0 0 12 0 0 0 % C
% Asp: 0 0 0 34 12 0 0 12 12 0 0 0 0 12 0 % D
% Glu: 45 0 12 0 12 12 12 0 12 12 0 0 0 12 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 12 12 0 0 0 % F
% Gly: 0 0 0 0 12 0 0 12 12 0 12 0 0 0 0 % G
% His: 0 0 0 0 34 12 0 0 12 0 0 0 0 0 12 % H
% Ile: 0 0 12 0 0 0 0 0 0 0 34 0 0 0 12 % I
% Lys: 0 45 0 0 12 45 12 0 12 12 0 0 0 0 0 % K
% Leu: 0 0 0 23 0 0 0 0 0 34 0 12 0 0 0 % L
% Met: 12 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 12 12 0 12 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 23 0 0 0 0 12 0 0 12 45 34 % P
% Gln: 12 23 0 0 0 0 12 12 0 0 12 45 0 0 23 % Q
% Arg: 0 12 0 0 0 12 0 0 12 23 12 12 23 0 0 % R
% Ser: 23 12 12 0 0 0 12 45 12 0 0 0 12 12 12 % S
% Thr: 0 0 34 12 0 0 0 0 12 0 0 0 34 0 0 % T
% Val: 0 0 12 0 0 12 0 0 0 0 23 0 0 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 12 0 12 0 0 0 % W
% Tyr: 0 12 0 0 0 0 12 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _